AGRP | AGRT Rabbit pAb (一抗) | Bioss

bs-7376R

AGRP | AGRT Rabbit pAb

褐黑素相关蛋白ART抗体

AGRT; ART; ASIP2; AGRP_HUMAN; AGRP; agouti related neuropeptide; agouti (mouse) related protein; agouti related protein homolog (mouse)

Rabbit

KLH conjugated synthetic peptide derived from human AGRP: 31-132/132

IgG

Liquid

affinity purified by Protein A

Polyclonal

12 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

AGRP

Agouti-related protein

Interacts with melanocortin receptors MC3R, MC4R and MC5R.

Secreted. Golgi apparatus lumen.

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Contains 1 agouti domain.

Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.