PIK3R2 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-52217R

重组兔单抗

PIK3R2 Recombinant Rabbit mAb

磷脂酰肌醇激酶p85β重组兔单抗

MPPH; MPPH1; P85B; p85; p85-BETA; p85beta; P85B_HUMAN; PIK3R2; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta (PI3-kinase subunit p85-beta | PtdIns-3-kinase regulatory subunit p85-beta); P85B_MOUSE; P85B_RAT; phosphoinositide-3-kinase regulatory subunit 2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase regulatory subunit beta

Rabbit

A synthesized peptide derived from human PI3 kinase p85 beta: 140-164

IgG

Liquid

affinity purified by Protein A

Recombinant

18A11

82 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷脂酰肌醇-3-激酶（PI3K）的调节亚单位，一种磷酸化PtdIns（4,5）P2（磷脂酰肌醇4,5-二磷酸）生成磷脂酰肌醇3,4,5-三磷酸（PIP3）的激酶。PIP3通过将含有PH结构域的蛋白（包括AKT1和PDPK1）招募到细胞膜上，激活参与细胞生长、存活、增殖、运动和形态的信号级联，发挥关键作用。通过其SH2结构域与活化（磷酸化）蛋白酪氨酸激酶结合，并充当转接器，介导p110催化单元与质膜的结合。间接调节自噬(出版：23604317). 在肝脏代谢超负荷期间，以内质网应激和/或胰岛素依赖的方式促进XBP1亚型2的核易位，因此在葡萄糖耐量改善中发挥作用。

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta

Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated). Interacts with NYAP1, NYAP2 and MYO16.

Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ.

Belongs to the PI3K p85 subunit family.
Contains 1 Rho-GAP domain.
Contains 2 SH2 domains.
Contains 1 SH3 domain.

Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.