TLR2 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt | Bioss

bsm-54147R

重组兔单抗

TLR2 Recombinant Rabbit mAb

Toll样受体2（CD282）抗体

CD282; TIL4; TLR2_HUMAN; TLR2; Toll/interleukin-1 receptor-like protein 4; toll like receptor 2; toll-like receptor 2

Rabbit

Recombinant human TLR2 protein: 1-600/784

IgG

Liquid

affinity purified by Protein A

Recombinant

3A27

84 kDa

100 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Toll样受体2（TLR2）通过激活天然免疫，参与特异性免疫应答的启动，Toll样受体2(TLR2)作为一种重要跨膜信号转导受体参与了内毒素诱发炎症反应的病理过程，对其调控机制的研究日益受到关注。

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008].

TLR2

Toll-like receptor 2

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3.

Membrane; Single-pass type I membrane protein.

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.