GRIN1 | GluN1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

Name: 离子型谷氨酸受体1重组兔单抗（GRIN1 | GluN1 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-52950R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书

货号：bsm-52950R

产品详情

概述

产品编号

bsm-52950R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

GRIN1 | GluN1 Recombinant Rabbit mAb

中文名称

离子型谷氨酸受体1重组兔单抗

英文别名

DEE101; GluN1; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; NMDAR1; NR1; hNR1; GluRdelta1; GluRzeta1; M100174; Nmdar; Rgsc174; NMDZ1_HUMAN; GRIN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1 (NMD-R1 | hNR1); NMDZ1_MOUSE; N-methyl-D-aspartate receptor subunit NR1 (NMD-R1); Glurz1; NMDZ1_RAT; glutamate ionotropic receptor NMDA type subunit 1; N-methyl-D-aspartate receptor subunit NR1; glutamate receptor, ionotropic, N-methyl D-aspartate 1

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human GluN1: 850-900

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

13C4

理论分子量

103 kDa

检测分子量

120 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Neuroscience > Cell Type Marker > Neuron marker > Growth Cone

Neuroscience > Neurology process > Neurogenesis

SWISS

Q05586

Gene ID

2902

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 2902 Human

Entrez Gene : 14810 Mouse

Entrez Gene : 24408 Rat

Omim : 138249 Human

SwissProt : Q05586 Human

SwissProt : P35438 Mouse

SwissProt : P35439 Rat

Unigene : 558334 Human

Unigene : 278672 Mouse

Unigene : 9840 Rat

产品介绍

神经细胞标志物

(NMDAR1)N-甲基-D-天门冬氨酸受体(NMDAR)是兴奋性氨基酸受体亚型之一，是由NMDAR1与不同的NMDAR2亚基组成的异聚体。
近年实验研究发现，许多NMDAR拮抗药均具有镇痛活性，表明NMDAR在痛觉传递中具有重要作用，这为新型镇痛药的研究开发提供了新的作用靶点。

背景资料

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

基因名

GRIN1

蛋白名

Glutamate receptor ionotropic, NMDA 1

亚基

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP.

亚细胞定位

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in post-synaptic plasma membrane and post-synaptic densities.

翻译后修饰

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

疾病

Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

相似性

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

功能

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.