英文名称
Gastrin 17 (G-17) Mouse mAb
免疫原
Recombinant human Gastrin 17
纯化方法
affinity purified by Protein A
储存液
0.01M PBS (pH7.4) with 0.02% Proclin300.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Gastrin又称蛙皮素（Bombesin），是一种含十七个氨基酸残基的多肽类激素。它是由胃黏膜产生，可刺激胃液、盐酸、及消化酶的分泌。Gastrin还可刺激平滑肌收缩、增加血液循环和胃肠道液体的分泌。
背景资料
Gastrin is responsible for epithelial cell proliferation and differentiation. Gastrin regulates the action of parietal cells in secretion of gastric acid and growth factors essential for stomach maintenance. Gastrin maintains sodium ion homeostasis and controls body’s blood pressure. Hypoxial conditions in in vitro and in vivo analysis may elevate the expression of gastrin hormone in cancer cells in order to promote angiogenesis. The only established clinical routine use of gastrin RIA so far is in the diagnosis, localization, and therapeutic control of gastrinomas (Zollinger–Ellison or Z–E tumors).
翻译后修饰
Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
相似性
Belongs to the gastrin/cholecystokinin family.
功能
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.