ICOS Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss

bsm-60227R

重组兔单抗

ICOS Recombinant Rabbit mAb

诱导协同刺激分子CD278重组兔单抗

AILIM; CD278; CVID1; ICOS_HUMAN; ICOS; Activation-inducible lymphocyte immunomediatory molecule; inducible T cell costimulator; inducible T-cell costimulator

Rabbit

A synthesized peptide derived from human ICOS: 40-95/199

IgG

Liquid

affinity purified by Protein A

Recombinant

F3H8

20 kDa

23 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.[provided by RefSeq, Jul 2008].

ICOS

Inducible T-cell costimulator

Homodimer; disulfide-linked.

Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 2: Secreted (Potential).

Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

N-glycosylated.

Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1) [MIM:607594]. CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).