PAX5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

Name: 配对盒基因5重组兔单抗（PAX5 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-60221R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书文献引用(2)

货号：bsm-60221R

产品详情

概述

产品编号

bsm-60221R

产品类型

重组兔单抗、病理级抗体

英文名称

PAX5 Recombinant Rabbit mAb

中文名称

配对盒基因5重组兔单抗

英文别名

ALL3; BSAP; PAX-5; EBB-1; KLP; PAX5_HUMAN; PAX5; B-cell-specific transcription factor (BSAP); PAX5_MOUSE; paired box 5; paired box gene 5 (B-cell lineage specific activator protein); paired box gene 5 (B-cell lineage specific activator); B-cell lineage specific activator

抗体来源

Rabbit

免疫原

KLH conjugated synthetic peptide derived from human PAX5

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

G7C4

理论分子量

42 kDa

检测分子量

45 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > PAX

Neuroscience > Neurology process > Neurogenesis

SWISS

Q02548

Gene ID

5079

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 5079 Human

Entrez Gene : 18507 Mouse

Omim : 167414 Human

SwissProt : Q02548 Human

SwissProt : Q02650 Mouse

产品介绍

同源结构域蛋白（Homeodomain Proteins） PAX-5属于转录抑制因子。在胚胎发育和肿瘤生长中起关键作用。其突变和某些肿瘤的发病有关。Pax-5基因是B细胞生成和B细胞发育的重要转录因子，是B细胞系特异性激活蛋白。在B细胞早期发育阶段，Pax-5能影响CD19、CD20等B细胞特异性基因的表达。它主要分布于前B细胞和成熟B细胞。该蛋白对B细胞和神经元的发育有重要作用。

背景资料

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

基因名

PAX5

蛋白名

Paired box protein Pax-5

亚基

Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4. Interacts with ETS1, altering its DNA-binding properties.

亚细胞定位

Nucleus.

组织特异性

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

翻译后修饰

O-glycosylated (Probable).

疾病

Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.

相似性

Contains 1 paired domain.

功能

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.