SOD2 | Mn-SOD Rabbit pAb (一抗) | Bioss

bs-23402R

宠物抗体、农牧业/家禽抗体

SOD2 | Mn-SOD Rabbit pAb

超氧化物歧化酶2抗体

MNSOD; SOD2X1; SOD2X2; GC1; GClnc1; IPO-B; IPOB; MVCD6; Mn-SOD; lncRNA-GC1; Sod-2; SODM_BOVIN; SOD2; 1.15.1.1; SODM_HUMAN; SODM_MOUSE; SODM_RABIT; SODM_RAT; superoxide dismutase 2; superoxide dismutase 2, mitochondrial; gastric cancer–associated lncRNA 1; manganese superoxide dismutase

Rabbit

KLH conjugated synthetic peptide derived from human SOD2: 21-120/222

IgG

Liquid

affinity purified by Protein A

Polyclonal

22 kDa

22 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SOD2是清除线粒体氧自由基的最主要的酶类，SOD2参与促进细胞分化和肿瘤发生。SOD2的表达缺乏与血管病变、新生儿致死、神经退行性病变有关联。SOD2过度表达与抵御细胞氧化损伤有关。
超氧化物歧化酶又称(Superoxide dismutase，简称SOD)是参与机体抗氧化（ROS，反应性氧离子reactive oxygen species）防御机制和抵御细胞氧化损伤最重要的酶类之一， 广泛存在于需氧生物、耐氧生物及某些厌氧微生物中，目前已知的SOD 主要分为三类，即胞质中Cu/Zn-SOD（即SOD1）、线粒体中的Mn-SOD（即SOD2）和ec-SOD(即SOD3)。

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SOD2

Superoxide dismutase [Mn], mitochondrial

Homotetramer.

Mitochondrion matrix.

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.

Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Belongs to the iron/manganese superoxide dismutase family.

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.