MCL1 | Mcl-1 Rabbit pAb (一抗) | Bioss

bs-23315R

宠物抗体、农牧业/家禽抗体

MCL1 | Mcl-1 Rabbit pAb

髓样细胞白血病-1抗体

BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT; Gm52627; MCL1_HUMAN; MCL1; Bcl-2-like protein 3 (Bcl2-L-3); Bcl-2-related protein EAT/mcl1; MCL1_MOUSE; MCL1_RAT; MCL1 apoptosis regulator, BCL2 family member; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia 1; MCL1, BCL2 family apoptosis regulator

Rabbit

KLH conjugated synthetic peptide derived from human MCL1: 101-200/350

IgG

Liquid

affinity purified by Protein A

Polyclonal

39 kDa

40 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Mcl1蛋白是bcl-2家族成员,它在调控肿瘤细胞的凋亡、增殖、分化等过程中起一定作用。

Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.

MCL1

Induced myeloid leukemia cell differentiation protein Mcl-1

Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins.

Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.

Belongs to the Bcl-2 family.

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.