SOX17 Rabbit pAb (一抗) | Bioss
货号：bs-12205R
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概述
产品编号
bs-12205R
产品类型
农牧业/家禽抗体
英文名称
SOX17 Rabbit pAb
中文名称
转录因子SOX17抗体
英文别名
PPH7; VUR3; SOX17_HUMAN; SOX17; SOX17_MOUSE; Sox-17; SRY-box transcription factor 17; SRY (sex determining region Y)-box 17; SRY-box 17
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from Human SOX17: 71-180/414
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
44 kDa
检测分子量
48 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Pig, Cow, Chicken | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Pig, Cow, Chicken | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Pig, Cow, Chicken | 1:100-500 |
| IF | Rat | Human, Mouse, Pig, Cow, Chicken | 1:100-500 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Pig, Cow, Chicken)
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靶标
基因名
SOX17
蛋白名
Transcription factor SOX-17
亚基
Interacts with CTNNB1, LEF1 and TCF4 (By similarity).
亚细胞定位
Nucleus.
组织特异性
Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
疾病
Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:613674]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
相似性
Contains 1 HMG box DNA-binding domain.
Contains 1 Sox C-terminal domain.
Contains 1 Sox C-terminal domain.
功能
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
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