ZDHHC17 Rabbit pAb (一抗) | Bioss

bs-6628R

宠物抗体、农牧业/家禽抗体

ZDHHC17 Rabbit pAb

NFκB激活蛋白205抗体

DHHC-17; DHHC17; HIP14; HIP3; HSPC294; HYPH; A230053P19Rik; D130071N24Rik; ZDH17_HUMAN; ZDHHC17; Acyltransferase ZDHHC17; DHHC domain-containing cysteine-rich protein 17 (DHHC17); Huntingtin yeast partner H; Huntingtin-interacting protein 14 (HIP-14); Huntingtin-interacting protein 3 (HIP-3); Huntingtin-interacting protein H; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; Zinc finger DHHC domain-containing protein 17; 2.3.1.225; KIAA0946; ZDH17_MOUSE; DHHC domain-containing cysteine-rich protein 17 (DHHC-17); Huntingtin-interacting protein 14; zDHHC palmitoyltransferase 17; zinc finger DHHC-type containing 17; zinc finger DHHC-type palmitoyltransferase 17

Rabbit

KLH conjugated synthetic peptide derived from human ZDHHC17: 365-460/632

IgG

Liquid

affinity purified by Protein A

Polyclonal

73 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ZDHHC17 is a neuronal palmitoyl transferase. Palmitoylation is critical for trafficking and function of signaling molecules, neurotransmitter receptors, and synaptic scaffolding proteins in neurons. ZDHHC17 causes cellular transformation. It has been shown that mRNA encoding ZDHHC17 is up-regulated in a number of types of human tumors, thus ZDHHC17 and other PATs (palmitoyl acyltransferases) are potential targets for new anticancer drugs.

ZDHHC17

Palmitoyltransferase ZDHHC17

Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.

Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.

Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Contains 5 ANK repeats.
Contains 1 DHHC-type zinc finger.

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.