CYP26A1 Recombinant Rabbit mAb (一抗) | Bioss

bsm-54341R

重组兔单抗

CYP26A1 Recombinant Rabbit mAb

细胞色素cP450 CYP26A1重组兔单抗

CP26; CYP26; P450RAI; P450RAI1; CP26A_HUMAN; CYP26A1; Cytochrome P450 retinoic acid-inactivating 1 (Cytochrome P450RAI | hP450RAI); Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome; 1.14.13.-; cytochrome P450 family 26 subfamily A member 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450, family 26, subfamily A, polypeptide 1

Rabbit

A synthesized peptide derived from human Cytochrome P450 26A1: 250-450

IgG

Liquid

affinity purified by Protein A

Recombinant

11A1

48 kDa

56 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.

CYP26A1

Cytochrome P450 26A1

Endoplasmic reticulum membrane. Microsome membrane.

Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.

Belongs to the cytochrome P450 family.

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.