Cyclin B2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

bsm-52045R

重组兔单抗、mIHC精品抗体

Cyclin B2 Recombinant Rabbit mAb

周期素B2重组兔单抗

HsT17299; CycB2; CCNB2_HUMAN; CCNB2; CCNB2_MOUSE; cyclin B2

Rabbit

Recombinant human Cyclin B2 protein (1-150a)

IgG

Liquid

affinity purified by Protein A

Recombinant

2F4

45 kDa

45 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin B2 belongs to a the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin B2 has been shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.

CCNB2

G2/mitotic-specific cyclin-B2

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Belongs to the cyclin family. Cyclin AB subfamily.

Essential for the control of the cell cycle at the G2/M (mitosis) transition.