Human IL-10 ELISA Kit (ELISA试剂盒) | Bioss

bsk11010

Human IL-10 ELISA Kit

白细胞介素10酶联免疫试剂盒

Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN.

0.78 - 50 pg/mL

0.39 pg/mL

cell culture supernates, serum, and plasma.

Human

S/P/CC

Store at 2-8°C for 12 months. Avoid multiple freeze-thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白细胞介素-10(IL-10)是主要由Th2细胞所产生的一种细胞因子，活化的B细胞、单核巨噬细胞和枯否氏细胞（Kupffer's cell）等也可产生IL-10。它是以抑制Th细胞克隆细胞因子合成为特点的多效免疫调节因子。 白介素-10是维护细胞因子网络平衡的重要负调节因子。其作用机制可能是降低抗原递呈细胞MHCⅡ类抗原表达，或诱导抗原递呈细胞产生另一种细胞因子，改变细胞内信号传递途径，从而选择性抑制某些细胞因子mRNA转录，并与Th2细胞产生的IL-4、IL-5有协同作用。

IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.