TEAD1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-63274R

重组兔单抗

TEAD1 Recombinant Rabbit mAb

TEAD1重组兔单抗

AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1; TEF-1; TEA domain transcription factor 1; atrophia areata, peripapillary chorioretinal degeneration; TEA domain family member 1 (SV40 transcriptional enhancer factor); transcriptional enhancer factor 1

Rabbit

A synthesized peptide derived from human TEAD1: 201-248/426

IgG

Liquid

affinity purified by Protein A

Recombinant

4C6

48 kDa

48-52 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

TEAD1

Transcriptional enhancer factor TEF-1

Interacts with YAP1 and WWTR1/TAZ.

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.