SIRT3 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-60944R

重组兔单抗

SIRT3 Recombinant Rabbit mAb

线粒体乙酰化酶3重组兔单抗

SIR2L3; 2310003L23Rik; SIR3_HUMAN; SIRT3; hSIRT3; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; 2.3.1.286; SIR3_MOUSE; SIR2-like protein 3 (mSIR2L3); sirtuin 3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)

Rabbit

KLH conjugated synthetic peptide derived from mouse SIRT3

IgG

Liquid

affinity purified by Protein A

Recombinant

2B6

43 kDa

28 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

SIRT3

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Interacts with NDUFA9, ACSS1, IDH2 and GDH.

Mitochondrion matrix.

Widely expressed.

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.

Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.

NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.