TFEB (p-S142) Rabbit pAb (一抗) - WB | Bioss

bs-22337R

磷酸化抗体、宠物抗体、农牧业/家禽抗体

TFEB (p-S142) Rabbit pAb

磷酸化T淋巴细胞转录调节因子TFEB抗体

TFEB_HUMAN; TFEB; Class E basic helix-loop-helix protein 35 (bHLHe35); BHLHE35; TFEB_MOUSE; Tcfeb; transcription factor EB; TFEB (phospho-S142); p-TFEB; phospho-TFEB; TFEB (phospho-Ser142)

Rabbit

KLH conjugated Synthesised phosphopeptide derived from human TFEB around the phosphorylation site of Ser142: PN(p-S)PM

IgG

Liquid

affinity purified by Protein A

Polyclonal

52 kDa

52 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

TFEB

Transcription factor EB

Homodimer and heterodimer; with TFE3 or MITF.

Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.

Sumoylated; does not affect dimerization with MITF.

Belongs to the MiT/TFE family.
Contains 1 basic helix-loop-helix (bHLH) domain.

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.