ITGB2 | Human CD18 Mouse mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-30018M

流式抗体

ITGB2 | Human CD18 Mouse mAb

小鼠抗人CD18单克隆抗体

CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; ITB2_HUMAN; ITGB2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; integrin subunit beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); complement component 3 receptor 3 and 4 subunit

Mouse

KLH conjugated synthetic peptide derived from human CD18

Mouse IgG1, k

Liquid

affinity purified by Protein G

Monoclonal

18F7

82 kDa

90-95 kDa

1mg/ml

0.01M PBS (pH7.4).

Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

LFA-1主要与除红细胞、血小板之外的人外周血各类白细胞反应，与骨髓、胸腺、扁桃体细胞、某些肿瘤细胞反应和表达。又称白细胞黏附蛋白。

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

ITGB2

Integrin beta-2

Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR. Interacts with COPS5 and RANBP9.

Membrane; Single-pass type I membrane protein.

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. Note=The disease is caused by mutations affecting the gene represented in this entry.

Belongs to the integrin beta chain family.
Contains 1 VWFA domain.

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.